Activation of MrgC receptor inhibits N-type calcium channels in small-diameter primary sensory neurons in mice
نویسندگان
چکیده
منابع مشابه
N-type calcium current, Cav2.2, is enhanced in small-diameter sensory neurons isolated from Nf1+/- mice.
Major aspects of neuronal function are regulated by Ca(2+) including neurotransmitter release, excitability, developmental plasticity, and gene expression. We reported previously that sensory neurons isolated from a mouse model with a heterozygous mutation of the Nf1 gene (Nf1+/-) exhibited both greater excitability and evoked release of neuropeptides compared to wildtype mice. Furthermore, aug...
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N-type calcium (Ca2+) channels play a critical role in synaptic function, but the mechanisms responsible for their targeting in neurons are poorly understood. N-type channels are formed by an alpha(1B) (Ca(V)2.2) pore-forming subunit associated with beta and alpha2delta auxiliary subunits. By expressing epitope-tagged recombinant alpha1B subunits in rat hippocampal neuronal cultures, we demonst...
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GPR35 is a G protein-coupled receptor recently "de-orphanized" using high-throughput intracellular calcium measurements in clonal cell lines expressing a chimeric G-protein alpha-subunit. From these screens, kynurenic acid, an endogenous metabolite of tryptophan, and zaprinast, a synthetic inhibitor of cyclic guanosine monophosphate-specific phosphodiesterase, emerged as potential agonists for ...
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ژورنال
عنوان ژورنال: Pain
سال: 2014
ISSN: 0304-3959
DOI: 10.1016/j.pain.2014.05.008